Is the MTHFR gene mutation really keeping you from healing?
Understanding the MTHFR Gene Mutation
The MTHFR gene is often the starting point for many when they first hear about how genes can affect health. It influences how our bodies process folate and homocysteine, both vital for overall health. When someone discovers they have an MTHFR mutation, they might blame it for their health issues, as it's the most well-known gene mutation discussed.
However, it's important to realize that the MTHFR gene doesn't work in isolation. Our overall genetic expression, lifestyle, and nutrients all contribute to health outcomes.
Jaclyn Downs, a functional genomics expert, shares in-depth insights about the MTHFR mutation's impact. She clarifies the difference between having a gene and its expression, which is not often discussed.
Your genes don't change, but their expression can—meaning external factors can influence how they affect your health.

The Truth About MTHFR Gene Expression
Jaclyn emphasizes that blaming the MTHFR gene for all health troubles can be misleading. All genes work in conjunction, and other genetic variants, co-factors, and nutrients play significant roles. For instance, the right co-factors like magnesium and B vitamins are crucial for gene function. Without them, even a healthy MTHFR gene can appear deficient.
The gene's expression can vary over time due to lifestyle or environmental changes. This means some people might experience no issues for years despite having the MTHFR mutation. Understanding this can help shift the focus from solely the mutation to a broader health perspective.
Effective Testing and MTHFR Supplements
People often wonder about the best ways to test for and manage MTHFR-related issues. Genetic testing gives a predisposition framework, but coupling it with functional lab tests provides clearer insights. Organic acids, heavy metals, and mycotoxin tests can reveal underlying concerns and help tailor effective treatments.
When it comes to supplements, starting slow and being cautious is key. MTHFR supplements and nutrients, like methylfolate and B12, should be introduced slowly to prevent overwhelming the system. Jaclyn recommends avoiding folic acid and increasing natural folate intake through greens and legumes.

Empowering Your Healing Journey with Functional Genomics
Understanding functional genomics can empower you to make informed health decisions. Jaclyn's holistic approach allows individuals to see the bigger picture and how gene interactions impact health. It's not just about the MTHFR mutation but comprehending the web of interconnected factors affecting your well-being.
For those looking to dive deeper, experts like Jaclyn Downs provide invaluable guidance through her research, book, and personalized genetic interpretation services.
If you suspect the MTHFR gene is influencing your health or simply wish to optimize your healing process, embracing a comprehensive approach to genomics and lifestyle can offer the empowerment you need.
Ready to take the next step? Consider testing and consulting with professionals who understand the intricacies of genetic expression and start your journey towards effective healing today!


EPISODES MENTIONED:
- 214// Is this Gene Mutation Making Your ADHD Worse?
- 216// ADHD and COMT Gene Mutation: Why You Need to Know
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